The section ‘EDAIC MCQs with answers and simplified explanations’ covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
Question: Identify the true statements regarding Protein binding:
- One alpha-1 acid glycoprotein molecule can bind a number of different drugs
- Albumin can bind to neutral drugs
- Local anaesthetics bind to alpha-1 globin
- Protein binding increases the volume of distribution
- Protein binding decreases renal secretion of drugs
Answers:
- false
- true
- true
- false
- false
Explanation:
- Most drugs are bound to one of the two proteins ie albumin or alpha-1 acid glycoprotein.
- The nature and extent of binding is dependent o the drug characteristics (acid/base, pka)
- Protein-binding extend the duration of action of the drug by making the drug unavailable for extraction (renal filtrationbut not active secretion) and metabolism (only the unbound drug is available for metabolism)
- Etensively bound drugs are restricted to the intravascular compartment that reduced their volume of distribution
- Albumin
- has multiple drug binding sites and can bind more than 1 drug at a given time. it binds.
- acidic and neutral compounds usually bind to albumin
- The level is reduced by catabolic states: burns, malignancy, renal/hepatic disease, pregnancy, old age, neonates
- warfarin, bilirubin, salicylates, phenytoin, sulfonamides, benzodiazepine, NSAIDs,penicillin,
- Alpha-acid glycoprotein
- generally binds basic drugs and has only 1 drug binding site per molecules
- local anaesthetics, beta-blockers, verapamil, quinidine, disopyramide
- A1-acid glycoprotein level increased in catabolic states: burns, renal transplant, malignancy, trauma, inflammatory diseases: RA, UC, Crohn’s, myocardial infarct level decreased in pregnancy, neonates
- Some bind specialized proteins
- ceruloplasmin: copper
- transferrin: iron
- transcortin: steroids
Mock-tests for EDAIC part-1 are now available for your practice and making you familiar with the exam pattern, and complexity. The practice will come in handy when the final exam FINALLY arrives. The tests have been launched keeping in mind the much needed last-minute practice and revision required for September 2021 exam.
You can take the test and gauge your preparation level. Detailed explanations are also available for desiring candidates. The exam result will be emailed to you with or without explanations as per your result.
DO NOT WASTE YOUR PRECIOUS TIME AND TAKE THE TEST NOW!
EDAIC Part-1 Mock-test (1), Paper A with MCQ explanations.
EDAIC mock-tests are designed to get you accustomed to the feel and pattern of the examination. These are time-limited question papers that mimic the difficulty level of EDAIC MCQ exams. For each paper, you will have a prefixed time slot of 2 hours (just like the real exam). After the submission, your score will be mailed to you with explanations (if you had opted for the test + explanation).
It is an excellent opportunity for practice and revision for the exam-going candidates.
You can take the mock test at your convenience making sure you have 2 uninterrupted hours as the test will close in 2 hours after you start the exam.
We recommend that you take the complete test (A and B) on the same day with at least 1-hour break between attempting Paper A and Paper B.\
For Mock test (1), Paper B with MCQ explanations click here.
Need some more practice. Click here for more free MCQs uploaded on the site.
The candidates sitting in the current examination or preparing for next year should try and read about the asked topic in daily ‘EDAIC MCQs with answers’ and indulge in active discussion with fellow students. In addition, you can join our Facebook group to stay updated with targetedaic content and MCQ discussion.
The ‘EDAIC MCQs with answers and simplified explanations’ section covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
