The section, ‘EDAIC Multiple Choice Questions’ with answers and simplified explanations, covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
Question: True statements regarding clearance
- Is defined as the amount of drug cleared from plasma per unit of time
- Can be more than the maximum rate at which the drug can be metabolised in the body
- Drugs with low clearance have higher half lives
- Is equal to the sum of renal clearance + hepatic metabolism
- Can contribute to the termination of action of a drug
Answers:
- false
- true
- true
- false
- true
Explanation:
Clearance: It represents the volume of blood completely cleared of the drug in a unit of time (ml/min). It is often expressed in terms of body weight or body surface area. The drug may be removed by metabolism (and excretion) or by redistribution between different compartments. Clearance attributable to excretion describes the removal of drugs from the body.
Clearance = drug removed by metabolism and redistribution to other body compartments
Redistribution of drugs is the principal cause of termination of action of induction agents
Drugs with high clearance tend to have shorter half lives
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The ‘EDAIC Multiple Choice Questions with answers and simplified explanations’ section covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
EDAIC Part-1 Mock-test (1), Paper A with MCQ explanations.
