EDAIC part-1: Questions with simplified explanations. FREE UPLOADS BY WWW.TARGETEDAIC.COM (40)

The section, EDAIC part-1: Questions with simplified explanations, covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.

Question: identify the prodrugs

1. Fospropofol
2. Levodopa
3. Dipiverfin
4. Clopidogrel
5. Sulfasalazine

Answers:

1. true
2. true
3. true
4. true
5. true

Explanation:

A prodrug can be defined as a drug substance that is inactive in the intended pharmacological actions and is must be converted into a pharmacologically active agent by metabolic or Physico-chemical transformation.

or

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

Examples:

prodrug       active metabolite

• codeine        morphine
• levodopa      dopamine
• enalapril        enalaprilat
• Dipivefrine     epinephrine
• prednisone     prednisolone
• clopidogrel     thio metabolite
• fospropofol     propofol
• Bacampicillin   ampicillin
• Acyclovir         acyclovir triphosphate
• Fluorouracil    fluorouracil monophosphate
• sulfasalazine  sulfapyridine and 5-aminosalicylic acid

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The ‘EDAIC part-1: Questions with simplified explanations’ section covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.