The section, EDAIC Multiple Choice Questions with simplified explanations, covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
Question: A 35-year-old man undergoing emergency laparotomy for a hemoperitoneum following blunt trauma abdomen. His records reveal that he has been taking 60 mg methimazole and 50mg an oral β-adrenergic blocker for acute hyperthyroidism (48 hours on therapy now). Appropriate perioperative therapy includes administration of
- potassium iodide
- hydrocortisone
- propranolol
- propylthiouracil
- lithium
Answers:
- true
- true
- true
- true
- true
Explanation:
It takes few weeks for a hy[erthyroid patient to achieve euthyroid state, and ideally patients should be rendered euthyroid before elective surgery. However, emergency procedure requires that you optimise and manage the thyroid status concomitantly in the period period.
Management strtergies that can be employed in acute thyrotoxicosis case:
- Potassium or sodium iodide. Iodine therapy blocks the release of prestored hormone and decreases iodide transport and oxidation in follicular cells.
- Cortisol. Iglucocorticoids may also reduce thyroid hormone secretion and peripheral conversion of T4 to T3.
- Beta blockers for management oftachycardia, dysrhythmias, and increased cardiac output.
- Propylthiouracil, methimazole and carbimazole are thiourea derivatives thatact by inhibiting synthesis of thyroid hormones by preventing organification and trapping of iodide to iodine and by inhibiting coupling of iodotyrosines.
- Lithium inhibits thyroid hormone release from the thyroid gland as well as decreasing thyroid hormone synthesis
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The ‘EDAIC Multiple Choice Questions with simplified explanations’ section covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.