The section, EDAIC Multiple Choice Questions with simplified explanations, covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
Question: True statements regarding CRPS
- Only affects the extremities
- CRPS1 and CPRS 2 have significantly different management strategies
- The Budapest criteria provide a specific and sensitive definition of CRPS
- Can develop spontaneously, without an antecedent injury
- Serum levels of the inflammatory markers like IL-1 and TNF-alpha are raised significantly
Answers:
- false
- false
- true
- true
- false
Explanation:
- CRPS usually affects the extremities – an arm, leg, hand or foot – but can affect any part of your body.
- Usually occurs after even trivial injury but, on occasion, can develop spontaneously.
- It is a painful and disabling disorder affecting one or more extremities showing signs of
- vasomotor (relating to the constriction and dilatation of blood vessels),
- sudomotor (stimulation of sweat glands),
- inflammatory, and
- trophic changes (changes brought about in tissues from interruption or destruction of the nerve, blood supply or both) in the affected extremity.
- Inflammatory markers such as interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α) + Neuroinflammatory mediators like Substance P are elevated in the local tissues in the limb showing signs of CRPS, but not systemically. There is also a suppression of anti-inflammatory cytokines like IL-4 and IL-10.
- The Budapest criteria have higher specificity and similar sensitivity as compared with the former International Association for Study of Pain, IASP criteria.
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The ‘EDAIC Multiple Choice Questions with simplified explanations’ section covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.