The section ‘EDAIC MCQs with answers and simplified explanations’ covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.
Question: Suitable antibiotic therapy for gram-positive diplococci isolated from a diabetic patient with a history of persistent cough, high-grade fever, pleuritic chest pain and occasional hemoptysis. Her chest x-ray reveals right-sided lobar pneumonia.
A. Gentamicin is the drug of choice in penicillin resistant cases B. Penicillin G is the drug of choice C. Carbenicillin and gentamicin D. Macrolides or vancomycin may be needed in penicillin resistant cases E. Ciprofloxacin should be added in all cases
Answers:
- false
- true
- false
- true
- false
Explanation:
- The likely source of infection in the patient is streptococcus pneumoniae, a lancet-shaped encapsulated gram-positive diplococcus.
- Found in the nasopharynx of 5–10% of healthy adults.
- Diabetic, immunocompromised, asplenic/ hyposplenism patients are more susceptible to infections.
- Typically, the onset is acute, with high fever, cough, and pleuritic chest pain and a chest x-ray show a single pneumonic patch. (as in the present case).
- The polysaccharide capsule of the bacteria is the prime determinant of its virulence. Antibodies against the capsular polysaccharide promote the killing of the bacterium. The bacterium is usually penicillin-sensitive and the initial therapy should start with the penicillin group unless resistance is documented. Penicillin G is the drug of choice for Gram-positive diplococci (pneumococcal pneumonia). Penicillin-resistant strains are sensitive to macrolides, vancomycin, tazobactam–piperacillin (tazocin), and fluoroquinolones
- Gentamycin is most effective on Gram-negative organisms. Other drugs that can be used are carbenicillin and ampicillin; however, they are not first-line. Ciprofloxacin is only moderately active against streptococci species.
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The ‘EDAIC MCQs with answers and simplified explanations’ section covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.