EDAIC MCQ (Multiple Choice Question) and answer. FREE UPLOADS BY WWW.TARGETEDAIC.COM (95)

The section, EDAIC MCQ (Multiple Choice Question) and answer, covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.

Question: Identify the true statements:

A Dopamine is a synthetic analogue of dobutamine
B Dopamine is a precursor of noradrenaline
C Dobutamine can cause hypotension
D Dobutamine acts on dopaminergic receptors
E Dopamine causes peripheral dilatation at high doses

Answers:

1. 1. False
   2. True
   3. True
   4. False
   5. False

• Dobutamine is a synthetic analogue of dopamine and is a β-adrenoceptor stimulating agent.
• Dopamine is the precursor of noradrenaline and releases noradrenaline from stores in the nerve endings in the heart.
• The conversion of dopamine to noradrenaline occurs in granulated vesicles and is dependent on the enzyme dopamine β-hydroxylase.
• Dobutamine is a derivative of isoprenaline with predominantly β1-adrenoceptor activity, thus making it a potent inotrope. It does, however, also have a β2-stimulating effect, which causes peripheral vasodilatation. This may result in hypotension and a fall in the diastolic pressure with reflex tachycardia.
• Dobutamine acts on adrenergic receptors in the following order: β1 > β2 > α. It has no action on dopaminergic receptors.
• Dopamine stimulates the heart by both β- and α-adrenergic responses and causes vasodilatation through its action on dopaminergic receptors. At high doses (>10 μg/ kg/min), dopamine causes predominant α adrenoceptor stimulation with peripheral vasoconstriction, increased peripheral vascular resistance and reduced renal blood flow.

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‘EDAIC MCQ (Multiple Choice Question) and answer’ covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.