EDAIC MCQ (Multiple Choice Question) and answer. FREE UPLOADS BY WWW.TARGETEDAIC.COM (80)

The section, EDAIC MCQ (Multiple Choice Question) and answer, covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.

Question: Identify the false statements regarding propofol: :

• It is a lipohyllic weak acid with pka of 11
• It is contraindicated in porphyria
• It is a potential trigger for malignant hyperthermia
• Maximum propofol infusion rates should not exceed 4.8 mg kg⁻¹ h⁻¹ for long-term sedation in intensive care patients
• Has clearance of 11 ml/kg/min

Answers:

1. 1. False
   2. True
   3. True
   4. False
   5. True

Explanation:

• Propofol is a 2,6-diisopropyl phenol and is a lipophilic weak acid (pK_a=11) (Table 1). It is very insoluble in water, so is formulated as a 1% aqueous solution (10 mg ml⁻¹) in an oil-in-water emulsion.
• IT is considered safe in patients of MH or porphyrias
• Recent guidelines recommend maximum propofol infusion rates of 4.8 mg kg⁻¹ h⁻¹ for long-term sedation in intensive care patients.
•  Clearance of propofol is approx. 25 ml/kg/min which is extremely high (greater than hepatic blood flow), suggesting additional extrahepatic, metabolism.

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‘EDAIC MCQ (Multiple Choice Question) and answer’ covers a different topic each day with the intent that candidates can prepare one small topic each day, making steady progress in their exam preparation.